Abstract
Local bilateral destruction with 1 M glutamic acid of neuronal structures located between ventral surface of the medulla oblongata and the retrofacial nucleus (subretrofacial area) in rats increases the amplitude of pulses from the phrenic nerve and lowers respiratory rate. Hypercapnia does not affect the amplitude of phrenic nerve pulses but increases respiratory rate. It is suggested that the amplitude of central respiratory activity is regulated by the central chemoreceptors with participation of neuronal structures located in the subretrofacial area.
Similar content being viewed by others
References
L. I. Kalakutskii, V. F. Pyatin, and O. L. Nikitin,Fiziol. Zh. SSSR,77, No. 5, 611 (1991).
V. F. Pyatin and B. Ya. Peskov,Fiziol. Zh. SSSR,34, No. 1, 104–112 (1988).
K. Budzinska, C. von Euler, F. F. Kao,et al., Acta Physiol. Scand.,124, 329–340 (1985).
T. Chonan, E. M. Adams, C. von Euler,et al., Respir. Physiol.,80, No. 1, 45–54 (1990).
H. Onimaru and I. Homma,Brain Res.,403, No. 2, 380–384 (1987).
M. E. Schlaefke, J. L. Kill, and H. H. Loeschcke,Pflugers Arch.,378, 135–152 (1979).
W. M. St. John, Q. Hwang, E. E. Nattie,et al., Respir. Physiol.,76, No. 2, 159–171 (1989).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 5, pp. 491–493, May, 1997
Rights and permissions
About this article
Cite this article
Pyatin, V.F., Tatarnikov, V.S. & Nikitin, O.L. Effect of bilateral destruction of the subretrofacial area on central inspiratory activity of the respiratory center and on the respiratory response to hypercapnia. Bull Exp Biol Med 123, 424–426 (1997). https://doi.org/10.1007/BF02445307
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02445307