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Effect of human apolipoprotein A-I gene on vasoactive properties of high density lipoproteins in rats of different age

  • V. V. Frol'kis
  • V. A. Kordyum
  • O. K. Kul'chitskii
  • S. N. Novikova
  • N. V. Sykalo
  • L. N. Bogatskaya
  • R. I. Potapenko
  • M. K. Burchinskaya
  • T. G. Mozzhukhina
  • D. M. Irodov
Physiology

Abstract

Vasodilatory activity of high density lipoproteins and the content of apolipoprotein A-I in these particles decreases in senescent rats in comparison with adult animals. Implantation of human apolipoprotein A-I gene increases the content of this apolipoprotein in high density lipoproteins and improves their vasodilatory effect.

Key Words

gene lipoproteins vessels aging 

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References

  1. 1.
    A. N. Klinov and N. G. Nikul'cheva,Lipoproteins, Dyslipoproteinemias, and Atherosclerosis [in Russian], Leningrad (1984).Google Scholar
  2. 2.
    V. V. Frol'kis, V. A. Kordyum, L. N. Bogatskaya,et al., Biopolimery i Kletki,7, No. 2, 103–109 (1991).Google Scholar
  3. 3.
    V. V. Frol'kis, V. A. Kordyum, S. N. Novikova,et al., Dokl. Akad. Nauk SSSR,316, 1264–1267 (1991).PubMedGoogle Scholar
  4. 4.
    V. V. Frol'kis, O. K. Kul'chitskii, N. V. Sykalo,et al., Dokl. Akad. Nauk Ukrainy, No. 5, 132–136 (1995).Google Scholar
  5. 5.
    V. V. Frol'kis, V. V. Bezrukov, and O. K. Kul'chitskii,The Aging Cardiovascular System. Physiology and Pathology, New York (1996).Google Scholar
  6. 6.
    V. V. Frol'kis, V. A. Kordyum, L. N. Bogatskaya,et al., Arch. Gerontol. Geriatr.,13, 225–236 (1991).CrossRefGoogle Scholar
  7. 7.
    A. M. Gotto and H. J. Pownall,Manual of Lipid Disorders, Baltimore (1992).Google Scholar
  8. 8.
    F. T. Lindgren, L. C. Jencen, and F. T. Hatch, in:Blood Lipids and Lioproteins: Quantification, Composition, and Metabolism, Chaper Inc., (1972), pp. 181–274.Google Scholar
  9. 9.
    L. Sjolin, F. Hellstrand, and B. Clementz,Acta Physiol. Scand.,102, 32A-33A (1978).Google Scholar
  10. 10.
    I. B. Swaney and K. S. Kuehl,Biochim. Biophys. Acta,446, 561–565 (1976).PubMedGoogle Scholar
  11. 11.
    Yu. P. Vedernikov, V. Z. Lankin, A. L. Tikhadze, and A. M. Vikhert,Basic Res. Cardiol.,83, 590–596 (1988).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • V. V. Frol'kis
    • 1
    • 2
  • V. A. Kordyum
    • 1
    • 2
  • O. K. Kul'chitskii
    • 1
    • 2
  • S. N. Novikova
    • 1
    • 2
  • N. V. Sykalo
    • 1
    • 2
  • L. N. Bogatskaya
    • 1
    • 2
  • R. I. Potapenko
    • 1
    • 2
  • M. K. Burchinskaya
    • 1
    • 2
  • T. G. Mozzhukhina
    • 1
    • 2
  • D. M. Irodov
    • 1
    • 2
  1. 1.Department of Physiology, Laboratory of Metabolism Regulation, Institute of GerontologyUkrainian Academy of Medical SciencesKiev
  2. 2.Department of Cellular Regulatory Mechanisms, Institute of Molecular Biology and GeneticsUkrainian Academy of SciencesKiev

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