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Epithelial hyperplasia in organotypical aggregate cultures from mouse embryonal lung cells

  • Oncology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The incidence of epithelial hyperplasia is studied in cultures of aggregates from epithelial and mesenchymal cells of embryonal lungs of intact and urethrane-treated Asn and C57B1 mice (transplacental urethrane, 3 g/kg). In the control, epithelial hyperplasia was detected in 5.9% Asn and in 9.9% C57B1 mice. In experimental aggregates epithelial hyperplasia was 54.3% in Asn and 39.8% in C57B1 mice (p<0.001). In aggregates with only one tissue component from experimental and another from control embryos, the incidence of epithelial hyperplasia was lower than in experimental animals: 27.1–28.3% (p<0.001) in Asn and 16.7–35.1% (p<0.05) in C57B1 mice.

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Authors and Affiliations

  1. Department of Carcinogens, Institute of Carcinogenesis, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow

    T. S. Kolesnichenko & E. E. Antoshina

Authors
  1. T. S. Kolesnichenko
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  2. E. E. Antoshina
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 6, pp. 673–676, June, 1998

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Kolesnichenko, T.S., Antoshina, E.E. Epithelial hyperplasia in organotypical aggregate cultures from mouse embryonal lung cells. Bull Exp Biol Med 125, 597–600 (1998). https://doi.org/10.1007/BF02445251

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  • DOI: https://doi.org/10.1007/BF02445251

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