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Isolation and characterization of ICO-160 monoclonal antibodies to CD95(Fas/APO-1) antigen that mediates apoptosis

  • Oncology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Isotype IgG2a monoclonal antibodies ICO-160, detecting CD95(Fas/APO-1) antigen, were isolated and characterized. They react with 26.8±15.6% donor lymphocytes in the indirect immunofluorescence test, do not react with granulocytes, erythrocytes, and platelets, and stain part of monocytes. Monoclonal antibodies ICO-160 induce apoptosis in CD95(Fas/APO-1)-positive cells.

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Authors and Affiliations

  1. N. N. Blokhin the Oncology Research Center, Russian Academy of Medical Sciences, Moscow

    E. R. Polosukhina, T. N. Zabotina, Yu. V. Shishkin, Z. G. Kadagidze & A. Yu. Baryshnikov

Authors
  1. E. R. Polosukhina
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  2. T. N. Zabotina
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  3. Yu. V. Shishkin
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  4. Z. G. Kadagidze
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  5. A. Yu. Baryshnikov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 6, pp. 670–673, June, 1998

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Polosukhina, E.R., Zabotina, T.N., Shishkin, Y.V. et al. Isolation and characterization of ICO-160 monoclonal antibodies to CD95(Fas/APO-1) antigen that mediates apoptosis. Bull Exp Biol Med 125, 594–596 (1998). https://doi.org/10.1007/BF02445250

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  • DOI: https://doi.org/10.1007/BF02445250

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