Abstract
The pyrimidine derivatives xymedone and diucifon decrease the activity of adenylate cyclase, as shown in experiments on thymocytes and lymphocytes of guinea pig lymph nodes and human peripheral blood lymphocytes. Inhibition of the enzyme depends on the subpopulation and species appurtenance of immunocompetent cells. The relationship between the results and effects of pyrimidine derivatives in experiment and clinical setting is discussed.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 6, pp. 663–665, June, 1998
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Slabnov, Y.D., Cherepnev, G.V., Karimova, F.G. et al. Effect of pyrimidine derivatives on adenylate cyclase system of immunocompetent cell regulationin vitro . Bull Exp Biol Med 125, 588–590 (1998). https://doi.org/10.1007/BF02445248
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DOI: https://doi.org/10.1007/BF02445248