Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 125, Issue 6, pp 576–578 | Cite as

Peripheral μ-Opiate receptors and modulation of myocardial tolerance to arrhythmogenic stimuli

  • Yu. B. Lishmanov
  • L. N. Maslov
  • A. V. Krylatov
Pharmacology and Toxicology
  • 20 Downloads

Abstract

The peripheral μ-opiate receptor agonists DALDA and PL017 are highly effective against arrhythmias induced by adrenaline, aconitine, or CaCl2. The effect was abolished by the μ-opiate receptor antagonist CTAP. It is likely that Ca-channel block is involved in antiarrhythmic effect of DALDA.

Key Words

peripheral μ-opiate receptors arrhythmias 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    T. I. Grekova, K. M. Resnikov, O. V. Vinokurova,et al., Eksper. Klin. Farmakol.,57, No. 2, 24–26 (1994).Google Scholar
  2. 2.
    M. Lazdinskii, G. F. Reno, In:Physiology and Pathophysiology of the Heart (Ed. N. Sperelakis) [in Russian],593–617, Moscow (1990).Google Scholar
  3. 3.
    Yu. B. Lishmanov, L. N. Maslov,Opioid Neuropeptides, Stress, and Adaptational Heart Resistance [in Russian], Tomsk (1994).Google Scholar
  4. 4.
    N. A. Mazur and A. Abdala,Pharmacotherapy of Arrhythmias [in Russian], Moscow (1995).Google Scholar
  5. 5.
    L. N. Maslov, A. V. Krylatov, and Yu. B. Lishmanov,Byull. Eksp. Biol. Med.,122, No. 7, 25–27 (1996).Google Scholar
  6. 6.
    S. D. Mikhailova, T. M. Semushkina, and N. A. Bebyanova,Kardiologiya,31, No. 1, 13–15 (1991).PubMedGoogle Scholar
  7. 7.
    A. I. Khankoeva, P. A. Galenko-Yaroshevskii, and A. S. Dukhanin,Byull. Eksp. Biol. Med.,122, No. 7, 45–47 (1996).Google Scholar
  8. 8.
    K.-J. Chang, E. T. Wei, A. Killian, and J.-K. J. Chang,J. Pharmacol. Exp. Ther.,227, 403–408 (1983).PubMedGoogle Scholar
  9. 9.
    W. F. Lubbe, A. I. Gilchrist, and R. K. Holland,J. Mol. Cell. Cardiol.,19, Suppl. N. 5, 23–33 (1987).PubMedGoogle Scholar
  10. 10.
    L. N. Maslov and Yu. B. Lishmanov,Clin. Exp. Pharmacol. Physiol.,22, 812–816 (1995).PubMedGoogle Scholar
  11. 11.
    J. T. Pelton, W. Kazmierski, K. Gulyaet al., J. Med. Chem.,29, 2370–2375 (1986).PubMedCrossRefGoogle Scholar
  12. 12.
    P. W. Schiller, T. M.-D. Nguyen, and N. N. Chang, —Ibid.,,32, No. 3, 698–703 (1989).PubMedCrossRefGoogle Scholar
  13. 13.
    J. E. Shook, P. K. Lemeke, C. A. Gehriget al., J. Pharmacol. Exp. Ther.,249, No. 1, 83–90 (1989).PubMedGoogle Scholar
  14. 14.
    N. Sperelakis and G. M. Wahler,Mol. Cell. Biochem.,82, 19–28 (1988).PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • Yu. B. Lishmanov
    • 1
  • L. N. Maslov
    • 1
  • A. V. Krylatov
    • 1
  1. 1.Department of Experimental Cardiology, Institute of CardiologySiberian Division of the Russian Academy of Medical SciencesTomsk

Personalised recommendations