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Possible contribution of epiphyseo-adrenocortical relations to antidepressive effect of imipramine

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Chronically administered of imipramine decreases, while the depressogen reserpine increases, the level of plasma corticosterone in rats. The only effect of reserpine is antidepressive. Epiphysectomy stimulates the endocrine response to reserpine and attenuates the antireserpine effect of imipramine. This may be caused by antidepressive effect of epiphyseal factors.

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Authors and Affiliations

  1. Department of Pharmacology, Department of Biochemistry, Stavropol Medical Academy, USSR

    E. B. Arushanyan, K. S. El'bek'yan & E. V. Beyer

Authors
  1. E. B. Arushanyan
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  2. K. S. El'bek'yan
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  3. E. V. Beyer
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 6, pp. 626–627, June, 1998

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Arushanyan, E.B., El'bek'yan, K.S. & Beyer, E.V. Possible contribution of epiphyseo-adrenocortical relations to antidepressive effect of imipramine. Bull Exp Biol Med 125, 553–554 (1998). https://doi.org/10.1007/BF02445237

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  • DOI: https://doi.org/10.1007/BF02445237

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