Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 122, Issue 6, pp 1202–1204 | Cite as

The antioxidant properties of histamine receptor blockers: a comparative study in a model system

  • P. V. Sergeev
  • S. A. Chukaev
Pharmacology and Toxicology

Abstract

Antioxidant activities of seven histamine receptor blockers are compared using a model system of multilayer liposomes, chemiluminescence analysis, and 2-thiobarbituric acidreactive substance assay. According to a decrease in the antioxidant activity, the drugs can be arranged as follows: diprazine, suprastin, tavegil, diazoline, dimedrol, phencarol, and ranitidine. The possible mechanisms of the antioxidant activity and the significance of the antioxidant properties of these drugs for experimental research and clinical practice are discussed.

Key Words

antihistamines antioxidant activity chemiluminescence 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    M. V. Bilenko,Ischemia- and Reperfusion-Induce Damage to the Internal Organs [in Russian], Moscow (1990).Google Scholar
  2. 2.
    Yu. A. Vladimirov,Pat. Fiziol., No. 4, 7–19 (1989).Google Scholar
  3. 3.
    G. I. Klebanov, I. V. Babenkova, Yu. O. Teselkin, et al.,Lab. Delo, No. 5, 59–62 (1988).PubMedGoogle Scholar
  4. 4.
    R. D. Seifulla and I. G. Borisova,Farmakol. Toksikol.,53, No. 6, 3–10 (1990).PubMedGoogle Scholar
  5. 5.
    V. N. Syrov, Z. A. Khushbaktova, V. M. Gukasov, et al.,Khim.-Farm. Zh.,21, No. 1, 59–62 (1987).Google Scholar

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • P. V. Sergeev
    • 1
  • S. A. Chukaev
    • 1
  1. 1.Russian State Medical UniversityMoscow

Personalised recommendations