Bulletin of Experimental Biology and Medicine

, Volume 122, Issue 6, pp 1202–1204 | Cite as

The antioxidant properties of histamine receptor blockers: a comparative study in a model system

  • P. V. Sergeev
  • S. A. Chukaev
Pharmacology and Toxicology


Antioxidant activities of seven histamine receptor blockers are compared using a model system of multilayer liposomes, chemiluminescence analysis, and 2-thiobarbituric acidreactive substance assay. According to a decrease in the antioxidant activity, the drugs can be arranged as follows: diprazine, suprastin, tavegil, diazoline, dimedrol, phencarol, and ranitidine. The possible mechanisms of the antioxidant activity and the significance of the antioxidant properties of these drugs for experimental research and clinical practice are discussed.

Key Words

antihistamines antioxidant activity chemiluminescence 


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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • P. V. Sergeev
    • 1
  • S. A. Chukaev
    • 1
  1. 1.Russian State Medical UniversityMoscow

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