Bulletin of Experimental Biology and Medicine

, Volume 122, Issue 2, pp 790–792 | Cite as

Differences between August and Wistar rats in stress reactions and in the development of adaptation to stress

  • M. G. Pshennikova
  • L. Yu. Golubeva
  • B. A. Kuznetsova
  • M. V. Shimkovich
  • E. V. Malysheva
  • I. Yu. Malyshev
General Pathology and Pathological Physiology


Control and acutely stressed August rats have corticosterone levels 62% and 15% higher, respectively, than their Wistar counterparts, indicating that the activity of stress-mediating hypothalamic-pituitary-adrenal system in August rats is higher. On the other hand, the intensity of stress reactions and, consequently, the degree of activation of this system in August rats are 40–50% lower, as is the blood level of creatine phosphokinase. During adaptation to stress, August and Wistar rats show a similar decrease in the stress reaction and in its damaging effects. However, judging from the blood corticosterone/insulin ratio, adaptation to stress in August rats coincides with intensification of catabolic processes and a reduction in the efficiency of energy production.

Key Words

Wistar rats August rats stress corticosterone insulin adaptation 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    V. M. Gukasov, P. V. Sergeev, R. D. Seifulla, and Yu. A. Vladimirov,Byull. Eksp. Biol. Med.,77, No. 1, 54–57 (1974).Google Scholar
  2. 2.
    R. Kvetnanskii, T. I. Belova, Z. Oprshalova,et al., Fiziol. Zh. SSSR,67, No. 4, 516–523 (1981).PubMedGoogle Scholar
  3. 3.
    Yu. B. Lishmanov, Zh. V. Trifonova, A. N. Tsibin,et al., Byull. Eksp. Biol. Med.,103, No. 4, 422–424 (1987).CrossRefGoogle Scholar
  4. 4.
    V. V. Malyshev, E. N. Ekimov, and N. S. Kameneva, in:Physiology of Extremal States and Individual Protection of Man [in Russian], Moscow (1982), pp. 528–533.Google Scholar
  5. 5.
    E. V. Malysheva, A. V. Zamotrinskii, and I. Yu. Malyshev,Byull. Eksp. Biol. Med.,118, No. 8, 126–129 (1994).Google Scholar
  6. 6.
    F. Z. Meerson,Adaptation Medicine: Mechanisms and Protective Effects of Adaptation [in Russian], Moscow (1993).Google Scholar
  7. 7.
    F. Z. Meerson and I. Yu. Malyshev,The Phenomenon of Adaptative Stabilization of Structures, and Protection of the Heart [in Russian], Moscow (1993).Google Scholar
  8. 8.
    F. Z. Meerson and M. G. Pshennikova,Adaptation to Stressful Situations and Physical Exercise [in Russian], Moscow (1988).Google Scholar
  9. 9.
    L. E. Panin,Biochemical Mechanisms of Stress [in Russian], Novosibirsk (1983).Google Scholar
  10. 10.
    M. I. Ryakhovskaya, G. S. Grinenko, and L. M. Alekseeva,Khim.-Farm. Zh., No. 4, 16–18 (1991).Google Scholar
  11. 11.
    K. V. Sudakov, V. A. Dushkin, and E. A. Yumatov,Vestn. Akad. Med. Nauk SSSR, No. 12, 32–39 (1981).PubMedGoogle Scholar
  12. 12.
    R. A. Davis, R. J. Kern, and R. Showalter,Proc. Natl. Acad. Sci. USA,75, No. 9, 4130–4134 (1978).PubMedCrossRefGoogle Scholar
  13. 13.
    A. M. Lefer and M. L. Olgetree, in:Acute and Long-Term Medical Management of Myocardial Ischemia, Eds. A. Hjarimsonet al., Goteborg (1978), pp. 229–237.Google Scholar
  14. 14.
    P. Libby, P. R. Maroko, and C. Bloor,J. Clin. Invest.,52, 599–607 (1973).PubMedCrossRefGoogle Scholar
  15. 15.
    G. Weber, R. L. Singhal, and S. K. Srivastava,Adv. Enzyme Regul.,3, 43–75 (1965).CrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • M. G. Pshennikova
    • 1
  • L. Yu. Golubeva
    • 1
  • B. A. Kuznetsova
    • 1
  • M. V. Shimkovich
    • 1
  • E. V. Malysheva
    • 1
  • I. Yu. Malyshev
    • 1
  1. 1.Institute of General Pathology and PathophysiologyRussian Academy of Medical SciencesMoscow

Personalised recommendations