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Bulletin of Experimental Biology and Medicine

, Volume 122, Issue 2, pp 790–792 | Cite as

Differences between August and Wistar rats in stress reactions and in the development of adaptation to stress

  • M. G. Pshennikova
  • L. Yu. Golubeva
  • B. A. Kuznetsova
  • M. V. Shimkovich
  • E. V. Malysheva
  • I. Yu. Malyshev
General Pathology and Pathological Physiology
  • 21 Downloads

Abstract

Control and acutely stressed August rats have corticosterone levels 62% and 15% higher, respectively, than their Wistar counterparts, indicating that the activity of stress-mediating hypothalamic-pituitary-adrenal system in August rats is higher. On the other hand, the intensity of stress reactions and, consequently, the degree of activation of this system in August rats are 40–50% lower, as is the blood level of creatine phosphokinase. During adaptation to stress, August and Wistar rats show a similar decrease in the stress reaction and in its damaging effects. However, judging from the blood corticosterone/insulin ratio, adaptation to stress in August rats coincides with intensification of catabolic processes and a reduction in the efficiency of energy production.

Key Words

Wistar rats August rats stress corticosterone insulin adaptation 

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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • M. G. Pshennikova
    • 1
  • L. Yu. Golubeva
    • 1
  • B. A. Kuznetsova
    • 1
  • M. V. Shimkovich
    • 1
  • E. V. Malysheva
    • 1
  • I. Yu. Malyshev
    • 1
  1. 1.Institute of General Pathology and PathophysiologyRussian Academy of Medical SciencesMoscow

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