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Spermatogenesis in rats after injection of the antitumor drug vepeside

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Stable morphological changes and disorders of spermatogenesis develop in the testicles of Wistar rats during 30 days after a single injection of vepeside in the maximum tolerance dose. By the end of experiment the morphology of the testicles gradually normalizes, but some quantitative parameters characterizing spermatogenesis remain shifted. The detected disorders are caused by the damaging effect of the drug on the cells of all layers of spermatogenic epithelium.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    E. D. Gol'dberg, T. G. Borovskaya, E. A. Timina, T. I. Fomina & V. E. Gol'dberg

Authors
  1. E. D. Gol'dberg
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  2. T. G. Borovskaya
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  3. E. A. Timina
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  4. T. I. Fomina
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  5. V. E. Gol'dberg
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 12, pp. 645–648, December, 1997

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Gol'dberg, E.D., Borovskaya, T.G., Timina, E.A. et al. Spermatogenesis in rats after injection of the antitumor drug vepeside. Bull Exp Biol Med 124, 1194–1197 (1997). https://doi.org/10.1007/BF02445117

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  • DOI: https://doi.org/10.1007/BF02445117

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