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Disturbances of hypoxanthine metabolism in the liver of resuscitated rats

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Catabolism of purine mononucleotides to hypoxanthine and xanthine in the liver is enhanced in rats resuscitated after a 6.5-min asphyxia. Reduced incorporation of14C-hypoxanthine into these nucleotides 30 min 1, and 3 days after resuscitation attests to its disturbed reutilization. This probably promotes activation of the xanthine oxidase reaction, leading to purine deficit and hyperproduction of reactive oxygen species.

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Authors and Affiliations

  1. Central Research Laboratory, State Medical Academy, Omsk

    P. P. Zolin & V. D. Konvai

Authors
  1. P. P. Zolin
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  2. V. D. Konvai
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 12, pp. 629–631, December, 1997

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Zolin, P.P., Konvai, V.D. Disturbances of hypoxanthine metabolism in the liver of resuscitated rats. Bull Exp Biol Med 124, 1180–1182 (1997). https://doi.org/10.1007/BF02445113

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  • DOI: https://doi.org/10.1007/BF02445113

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