Bulletin of Experimental Biology and Medicine

, Volume 124, Issue 6, pp 1170–1173 | Cite as

Role of proliferation and differentiation of hemopoietic precursors in regeneration of hemopoiesis in cytostatic myelodepressions

  • A. M. Dygai
  • V. V. Zhdanov
  • M. Yu. Minakova
  • V. M. Ryzhakov
  • E. D. Gol'dberg
General Pathology and Pathological Physiology


Quantitative and qualitative composition of hemopoietic tissue and the intensity of proliferation and differentiation of committed hemopoietic precursors are studied in mice treated with adriamycin, cyclophosphane, or 5-fluorouracil. It is shown that intense maturation of colony-forming units results in rapid regeneration of hemopoiesis even under conditions of reduced proliferation of these cells, whereas inhibition of their differentiation suppresses restoration of bone marrow cellularity despite intense proliferation of hemopoietic precursors.

Key Words

precursors cells hemopoiesis myelodepression 


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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • A. M. Dygai
    • 1
  • V. V. Zhdanov
    • 1
  • M. Yu. Minakova
    • 1
  • V. M. Ryzhakov
    • 1
  • E. D. Gol'dberg
    • 1
  1. 1.Institute of Pharmacology, Tomsk Research CenterRussian Academy of Medical SciencesTomskRussia

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