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Peculiarities of Ca2+-induced erythrocyte response in patients with lung cancer undergoing antitumor chemotherapy

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Characteristics of changes in the membrane potential induced by increased Ca2+ inward current in patients with lung cancer are presented. Both the amplitude and the rate of hyperpolarization induced by opening of Ca2+-activated potassium channels are markedly decreased in erythrocytes from patients in comparison with healthy donors. Under conditions of moderate Ca2+ inward current, hyperpolarization is followed by restoration of the membrane potential. This process is more rapid in cancer patients. It is shown that the parameters of hyperpolarization, in their dynamics during antitumor therapy depend on the type of lung cancer.

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Authors and Affiliations

  1. Siberian Medical University, Tomsk, Tomsk, USSR

    I. V. Petrova, E. A. Stepovaya, I. B. Sokolova, V. E. Gol'dberg, N. Yu. Chasovskikh, K. G. Koreshkova, N. G. Bazhenova, M. V. Kolosova, M. B. Baskakov, V. V. Novitskii & M. A. Medvedev

  2. Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Science, Tomsk, USSR

    I. V. Petrova, E. A. Stepovaya, I. B. Sokolova, V. E. Gol'dberg, N. Yu. Chasovskikh, K. G. Koreshkova, N. G. Bazhenova, M. V. Kolosova, M. B. Baskakov, V. V. Novitskii & M. A. Medvedev

  3. Institute of Oncology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Science, Tomsk, USSR

    I. V. Petrova, E. A. Stepovaya, I. B. Sokolova, V. E. Gol'dberg, N. Yu. Chasovskikh, K. G. Koreshkova, N. G. Bazhenova, M. V. Kolosova, M. B. Baskakov, V. V. Novitskii & M. A. Medvedev

Authors
  1. I. V. Petrova
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  2. E. A. Stepovaya
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  3. I. B. Sokolova
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  4. V. E. Gol'dberg
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  5. N. Yu. Chasovskikh
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  6. K. G. Koreshkova
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  7. N. G. Bazhenova
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  8. M. V. Kolosova
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  9. M. B. Baskakov
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  10. V. V. Novitskii
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  11. M. A. Medvedev
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 195–198, August, 1997

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Petrova, I.V., Stepovaya, E.A., Sokolova, I.B. et al. Peculiarities of Ca2+-induced erythrocyte response in patients with lung cancer undergoing antitumor chemotherapy. Bull Exp Biol Med 124, 795–797 (1997). https://doi.org/10.1007/BF02445095

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  • DOI: https://doi.org/10.1007/BF02445095

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