Skip to main content
SpringerLink
Log in

Effect of piracetam administration to suckling rats on morphometry of neocortex and hippocamp

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The frontoparietal and parietal lobes of neocortex and hippocamp were studied in one-month-old rats, which were daily given piracetam 1000 mg/kg i.p., starting from the 5th day of life. In piracetam-treated animals, an increase in the thickness of cortex in frontoparietal lobe and of the size of neuronal nuclei both in layer V of parietal and frontoparietal lobes of neocortex, and in zones CA1-CA5 in hippocamp were observed. RNA concentration increased in neuronal cytoplasm in layer V of neocortex and in hippocamp. The brain mass, the density of neurons in the neocortex (layers II and V), the cortical thickness of neocortex in the parietal lobe did not differ in the control and experimental groups.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. G. G. Avtandilov,Medical Morphometry [in Russian], Moscow (1990).

  2. T. A. Voronina, S. V. Krapivin, and N. N. Bogolepov,Vestn. Akad. Med. Nauk SSSR, No. 2, 17–27 (1978).

    Google Scholar 

  3. N. I. Dmitrieva,Arkh. Anat.,83, No. 9 84–89 (1982).

    PubMed  CAS  Google Scholar 

  4. T. L. Karaseva, Zh. N. Tsapenko, N. Ya. Golovenko,et al., Vopr. Med. Khimii, No. 3, 81–84 (1988).

    Google Scholar 

  5. V. O. Klenikova, T. S. Glushchenko, S. Guneva, and Ts. Tencheva,Fiziol. Zh. SSSR.,68, No. 1, 9–12 (1982).

    PubMed  CAS  Google Scholar 

  6. T. V. Kovalev,Nootropic Preparations [in Russian], Volgograd (1991).

  7. B. Ya. Ryzhavskii and S. I. Biryukova,Byull. Eksp. Biol. Med.,116, No. 12, 641–642 (1993).

    Google Scholar 

  8. B. Ya. Ryzhavskii and S. I. Ivashkina,,120, No. 9, 305–307 (1995).

    CAS  Google Scholar 

  9. V. M. Svetukhina,Arkh. Anat.,42, No. 2, 31–46 (1962).

    PubMed  CAS  Google Scholar 

  10. I. V. Sirotina and Z. D. Aleksandrova,Eksp. Klin. Farmakol.,55, No. 1, 53–56 (1992).

    PubMed  CAS  Google Scholar 

  11. S. S. Trofimov and R. U. Ostrovskaya,Byull. Eksp. Biol. Med.,121, No. 4, 435–437 (1996).

    Article  CAS  Google Scholar 

  12. A. A. Khachaturyan,A Comparative Anatomy of the Cerebral Cortex in Humans and Primates [in Russian], Moscow (1988).

  13. F. Hucho,Neurochemistry: Fundamentals and Concepts, [Russian translation], Moscow (1990).

  14. G. I. Shul'gina and N. V. Okhotnikov,Zh. Vyssh. Nervn. Deyat.,40, No. 4, 732–738 (1990).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Histology of the State Far-Eastern Medical University, Khabarovsk

    B. Ya. Ryzhavskii, V. A. Cheprakova & D. A. Tsekatunov

  2. Department of Pharmacology of the State Far-Eastern Medical University, Khabarovsk

    B. Ya. Ryzhavskii, V. A. Cheprakova & D. A. Tsekatunov

Authors
  1. B. Ya. Ryzhavskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. A. Cheprakova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. A. Tsekatunov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 154–156, August, 1997

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ryzhavskii, B.Y., Cheprakova, V.A. & Tsekatunov, D.A. Effect of piracetam administration to suckling rats on morphometry of neocortex and hippocamp. Bull Exp Biol Med 124, 757–759 (1997). https://doi.org/10.1007/BF02445083

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02445083

Key Words

Search

Navigation