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Anticonvulsive and neurotoxic effects of lamictal (lamotrigine) in combination with other anticonvulsive preparations

  • General Pathology and Pathological Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In the model of electroshock convulsions combined administration of lamictal with other anticonvulsants (sodium valproate, phenobarbital, Diphenine, carbamazepine, ethosuximide, diazepam, and riodipin) decreased ED50 of each preparation by 1.9–4.2 times. The effectiveness of combination with carbamazepine was the highest: its therapeutic index was higher than that of each ingredient preparation.

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Authors and Affiliations

  1. Laboratory of Biochemistry, Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    M. N. Karpova, I. Yu. Abrosimov & G. N. Kryzhanovskii

  2. Laboratory of Neurochemical Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    K. S. Raevskii

Authors
  1. M. N. Karpova
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  2. I. Yu. Abrosimov
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  3. G. N. Kryzhanovskii
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  4. K. S. Raevskii
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 141–143, August, 1997

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Karpova, M.N., Abrosimov, I.Y., Kryzhanovskii, G.N. et al. Anticonvulsive and neurotoxic effects of lamictal (lamotrigine) in combination with other anticonvulsive preparations. Bull Exp Biol Med 124, 744–746 (1997). https://doi.org/10.1007/BF02445079

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  • DOI: https://doi.org/10.1007/BF02445079

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