Bulletin of Experimental Biology and Medicine

, Volume 124, Issue 1, pp 701–705 | Cite as

Comparative analysis ofMacaca arctoides STLV-1env gene sequenced fragment coding for the gp46 immunodominant site with HTLV-1 (ATK) and STLV-1 of different primates

  • M. G. Chikobava
  • L. A. Yakovleva
  • L. V. Indzhiya
  • B. A. Lapin
Microbiology and Immunology


Comparative analysis of the results of sequencing of the immunodominant site of STLV-1env gene ofMacaca arctoides (amino acid residues 176–256) with analogous sites of STLV-1 of different primates and with HTLV-1 showed that the majority of nucleotide replacements at this site of STLV-1 (81.8%) represent silent translation push mutations of the transition type. These replacements of STLV-1 amino acids possess hydrophobic and chemical properties similar to those of amino acid residues at the same positions of HTLV-1 and slightly affect spatial organization of the polypeptide carcass of ENV protein.

Key Words

STLV-1 HTLV-1 immunodominant site 


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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • M. G. Chikobava
    • 1
  • L. A. Yakovleva
    • 1
  • L. V. Indzhiya
    • 1
  • B. A. Lapin
    • 1
  1. 1.Institute of Medical PrimatologyRussian Academy of Medical SciencesSochi

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