Skip to main content
SpringerLink
Log in

Changes in neurons of the caudate nucleus in experimental alcoholism

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Reversible changes in caudate neurons and their dendrites in line with the components of compensatory reaction in oligodendrocytes are observed in rats during the first 3 weeks of a 12-month alcoholization period. After 2–4 months of alcoholization (the development of dependency), degenerative changes occur in caudate neurons and their dendrites system were evident. By the end of the 12-month period of alcohol intoxication, intensified deafferentation of the dendritic system was observed, suggesting functional insufficiency of the caudate nucleus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. T. M. Vorob'eva, Zh. P. Gordienko, and L. N. Paikova,Zn. Nevropatol. Psikhiatr.,90, No. 2, 77–84 (1990).

    Google Scholar 

  2. T. M. Vorob'eva and L. N. Paikova,Zh. Nevropatol. Psikhiatr.,93, No. 5, 85–90 (1993).

    PubMed  Google Scholar 

  3. L. Sh. Galeeva, “Forensic medical evaluation of morphological changes in the brain and selected viscera in alcohol intoxication,” Author's Synopsis of Dissertation [in Russina], Karaganda (1973).

  4. L. S. Kaminskii,Statistical Processing of Laboratory and Clinical Data [in Russian], Moscow (1964).

  5. G. N. Krivitskaya, V. B. Gel'fand, and E. N. Popova,Destructive and Reparative Processes in Focal Lesions of the Brain [in Russian], Moscow (1980).

  6. V. A. Otellin and E. B. Arashunyan,The Nigrostriatonigral System [in Russian], Moscow (1980).

  7. E. N. Popova, V. B. Polyanskii, K. A. Nikol'skaya,et al.,The Brain and Alcohol [in Russian], Moscow (1984).

  8. S. A. Sarkisov,Essays on Structure and Function of the Brain [in Russian], Moscow (1964).

  9. O. S. Sotnikov,Structural Dynamics of the Living Neuron [in Russian], Leningrad (1985).

  10. N. F. Suvorov,Fiziol. Zh.,80, No. 1, 3–13 (1994).

    CAS  Google Scholar 

  11. B. F. Tolkunov, K. B. Shipovalova, and S. V. Afanas'ev,Zh. Vyssh. Nervn. Deyat.,40, No. 6, 1027–1038 (1990).

    CAS  Google Scholar 

  12. O. G. Chivilyaeva, in:The Striatal System in Health and Disease [in Russian], Leningrad (1988), pp. 130–132.

  13. V. T. Shuvaev,Fiziol. Zh.,79, No. 5, 138–148 (1993).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Brain Ultrastructure, Institute of Brain, Russian Academy of Medical Sciences, Moscow

    E. N. Popova

Authors
  1. E. N. Popova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 66–69, July, 1997

Rights and permissions

Reprints and permissions

About this article

Cite this article

Popova, E.N. Changes in neurons of the caudate nucleus in experimental alcoholism. Bull Exp Biol Med 124, 679–682 (1997). https://doi.org/10.1007/BF02445060

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02445060

Key Words

Search

Navigation