Abstract
Exposure of HeLa cells to λ-radiation at 0.1 Gy and then at 5 Gy reduces their ability to repair double-strand DNA breaks to a greater extent than irradiation with a single dose of 5 Gy. Modifying effects of 0.1 Gy on double-strand DNA breaks and on cell survival are observed after irradiation during logarithmic but not stationary phase of growth. Primary λ-induced irreparable double-strand breaks correlates with cell survival regardless the irradiation regime. It is suggested that such a damage is primarily responsible for reproductive death of HeLa cells.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 53–56, July, 1997
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Struchkov, V.A., Demidova, N.I. & Strazhevskaya, N.B. λ-Radiation-induced irreparable damage to DNA of HeLa cells. Bull Exp Biol Med 124, 668–671 (1997). https://doi.org/10.1007/BF02445057
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DOI: https://doi.org/10.1007/BF02445057