Bulletin of Experimental Biology and Medicine

, Volume 124, Issue 1, pp 635–638 | Cite as

Mechanism of heart-rate acceleration caused by stimulation of vagal centers in the frog

  • V. M. Smirnov


The mechanism by which heart rate is increased upon stimulation of vagal centers is studied using frog heart preparations perfused with Ringer—Locke solution containing atropine and/or benzohexonium. Atropine stimulates vagus-induced heart-rate acceleration in dilutions of 10−6 and 10−5 g/ml. In a dilution of 10−4 g/ml both atropine and benzohexonium abolish vagal tachycardia. Rausedyl (3–4 injections, 5 mg/kg, at 18–20-h interval) prevents tachycardia. Stimulation of both halves of the medulla oblongata increases heart rate to a greater extent than stimulation of one half.

Key Words

heart regulation vagus 


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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • V. M. Smirnov
    • 1
  1. 1.Department of PhysiologyRussian State Medical UniversityMoscow

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