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Bulletin of Experimental Biology and Medicine

, Volume 120, Issue 3, pp 959–961 | Cite as

Formation of a complex of human plasma myeloperoxidase and opsonins

  • O. Yu. Yankovskii
  • I. A. Yablunovskaya
  • V. N. Kokryakov
  • G. M. Aleshina
  • N. Yu. Govorova
  • L. R. Khilazhetdinova
  • Yu. V. Gavrilova
Experimental Methods for Clinical Practice
  • 22 Downloads

Abstract

Human neutrophil myeloperoxidase adsorbs on immobilized fibronectin or IgG under conditions approaching the physiological ones. Immobilized myeloperoxidase binds liquid-phase plasma fibronectins and thermoaggregated IgG, but not native IgG. Protein-myeloperoxidase interaction is thought to be the mechanism arming phagocytes with this enzyme in the course of phagocytosis of pathogenic microorganisms and to be one means of preventing tissue injury by oxidants generated by extracellular myeloperoxidase.

Key words

myeloperoxidase opsonins protein-protein interaction 

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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • O. Yu. Yankovskii
    • 1
    • 2
  • I. A. Yablunovskaya
    • 1
    • 2
  • V. N. Kokryakov
    • 1
    • 2
  • G. M. Aleshina
    • 1
    • 2
  • N. Yu. Govorova
    • 1
    • 2
  • L. R. Khilazhetdinova
    • 1
    • 2
  • Yu. V. Gavrilova
    • 1
    • 2
  1. 1.Research Institute of Extra-Pure BiopreparationsMinistry of the Biomedical IndustrySt. Petersburg
  2. 2.Institute of Experimental MedicineRussian Academy of Medical SciencesSt. Petersburg

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