Formation of a complex of human plasma myeloperoxidase and opsonins
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Human neutrophil myeloperoxidase adsorbs on immobilized fibronectin or IgG under conditions approaching the physiological ones. Immobilized myeloperoxidase binds liquid-phase plasma fibronectins and thermoaggregated IgG, but not native IgG. Protein-myeloperoxidase interaction is thought to be the mechanism arming phagocytes with this enzyme in the course of phagocytosis of pathogenic microorganisms and to be one means of preventing tissue injury by oxidants generated by extracellular myeloperoxidase.
Key wordsmyeloperoxidase opsonins protein-protein interaction
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