Formation of a complex of human plasma myeloperoxidase and opsonins
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Human neutrophil myeloperoxidase adsorbs on immobilized fibronectin or IgG under conditions approaching the physiological ones. Immobilized myeloperoxidase binds liquid-phase plasma fibronectins and thermoaggregated IgG, but not native IgG. Protein-myeloperoxidase interaction is thought to be the mechanism arming phagocytes with this enzyme in the course of phagocytosis of pathogenic microorganisms and to be one means of preventing tissue injury by oxidants generated by extracellular myeloperoxidase.
Key wordsmyeloperoxidase opsonins protein-protein interaction
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- 1.N. A. Bezvershenko,Affinity Chromatography [in Russian], Kiev (1978).Google Scholar
- 2.I. Broque, in:Methods of Immunology [Russian translation], Ed. G. Friemel, Moscow (1987).Google Scholar
- 3.E. Boehm,Ibid. in:Methods of Immunology [Russian translation], Ed. G. Friemel, Moscow (1987).Google Scholar
- 4.S. D. Varfolomeev and S. V. Zaitsev,Kinetic Methods in Biochemical Studies [in Russian], Moscow (1982).Google Scholar
- 5.J. Kihoe, in:Immunoglobulins, Ed. G. W. Litman and R. A. Good, Plenum Press, New York (1978).Google Scholar
- 6.V. E. Pigarevskii,Granular Leukocytes and Their Properties [in Russian], Moscow (1978).Google Scholar
- 7.Ya. Turkova,Affinity Chromatography [in Russian], Mocscow (1980).Google Scholar
- 8.O. Yu. Yankovskii, N. Yu. Govorova, B. P. Sharonov, and S. N. Lyzlova,Vestn. Leningrad. Univers., Ser. 3,1, 71–76 (1988).Google Scholar
- 12.S. J. Klebanoff, in:Inflammation: Basic Principles and Clinical Correlates Eds. J. I. Gallinet al., New York (1992), pp. 541–588.Google Scholar