Abstract
The effects of morphine on the pain sensitivity and motor activity of progeny obtained by different variants of crossing purestrain WAG/G and Fischer-344 rats are studied. Four groups of rats were investigated: WAG/G (male and female WAG/G rats were crossed), Fischer-344 (Fischer-344 male and female), F/W (Fischer-344 male, WAG/ G female) F1 hybrids, and W/F (WAG/G male, Fischer-344 female) F1 hybrids. It is shown that the inheritance of individual features of sensitivity to the analgetic effect of morphine as well as of pain sensitivity is apparently sex-linked.
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E. V. Borisova, D. Yu. Rusakov, and S. K. Sudakov,Byull. Eksp. Biol. Med.,114, No 9, 296–298 (1992).
J. K. Belknap, J. C. Crabbe, J. Riggan,et al., Psychopharmacology,112, 352–358 (1993).
G. P. Horowitz, in:Development of Animal Models as Pharmacogenetic, Bethesda (1981), pp. 209–231.
C. P. O'Brien, R. N. Eherman, and J. W. Ternes,Behavioral Analysis of Drug Dependence, Ed. S. R. Goldberg, New York (1986), pp. 329–356.
A. Oliverio and C. Castellano,Psychopharmacologia,39, 13–22 (1974).
S. K. Sudakov, M. A. Konstantinopolsky, L. A. Surkova,et al., Drug Alcohol Depend.,29, 69–75 (1991).
S. K. Sudakov, R. S. Goldberg, E. V. Borisova,et al., Psychopharmacology,112, 183–188 (1993).
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 9, pp. 291–293, September, 1995
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Sudakov, S.K., Lyupina, Y.V. Inheritance of morphine sensitivity in (WAG/G-fischer-344) F1 rats. Bull Exp Biol Med 120, 930–932 (1995). https://doi.org/10.1007/BF02445020
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DOI: https://doi.org/10.1007/BF02445020