Effects of glucose and glutamine on the intensity of NAD precursor utilization in rats with transplanted tumors
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The rate of nicotinamide utilization for the biosynthesis of NAD both in the liver and kidneys and in tumor tissue of rats with Walker's carcinosarcoma and Pliss' lymphosarcoma is shown to be limited by glucose. Glucose and glutamine increase the utilization of nicotinic acid in the liver and kidneys of rats with Walker's carcinosarcoma, in the kidneys of rats with Pliss' lymphosarcoma, and to a lesser extent, in Pliss' lymphosarcoma tumor tissue, but do not affect the utilization of nicotinic acid in Walker's carcinosarcoma. It is concluded that certain stages of the NAD biosynthesis pathway are impaired.
Key WordsNAD nicotinamide nicotinic acid glucose glutamine rat tumors
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