Abstract
Tocopherol-enriched liver microsomes are more resistant to lipid peroxidation at an alkaline pH of 8.5 in comparison with microsomes incubated at pH 7.5. An alkaline pH provides conditions for two-electron oxidation of tocopherol, which causes the lipid molecule to revert to the initial state (O2/H exchange). A possible mechanism of inhibition of lipid peroxidation within the physiological range of pH with participation of a glutathione-dependent enzyme is discussed.
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Translated fromByullenten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 9, pp. 268–270, September, 1995
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Dmitriev, L.F., Ivanova, M.V. & Lebedev, A.V. Effect of pH and glutathione on lipid peroxidation in tocopherol-enriched liposomes. Bull Exp Biol Med 120, 908–910 (1995). https://doi.org/10.1007/BF02445013
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DOI: https://doi.org/10.1007/BF02445013