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Mechanisms responsible for the resistance of tracheal smooth muscle to histamine in rats

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A mechanographic study of contractile responses by tracheal smooth muscle segments of rats to a histaminergic agent showed that intact segments did not respond to histamine in the concentrations used (0.01–10 μM), whereas depolarized segments responded to histamine by dose-dependent contraction which were considerably enhanced following mechanical removal of the tracheal epithelium.

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Authors and Affiliations

  1. Department of Biophysics, Siberian Medical University, Tomsk

    L. V. Kapilevich, M. B. Baskakov, M. A. Medvedev, M. V. Kuskov, I. V. Kovalev & E. Yu. Petrov

Authors
  1. L. V. Kapilevich
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  2. M. B. Baskakov
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  3. M. A. Medvedev
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  4. M. V. Kuskov
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  5. I. V. Kovalev
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  6. E. Yu. Petrov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 9, pp. 263–264, September, 1995

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Kapilevich, L.V., Baskakov, M.B., Medvedev, M.A. et al. Mechanisms responsible for the resistance of tracheal smooth muscle to histamine in rats. Bull Exp Biol Med 120, 903–904 (1995). https://doi.org/10.1007/BF02445011

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  • DOI: https://doi.org/10.1007/BF02445011

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