Skip to main content
SpringerLink
Log in

Influence of basic fibroblast growth factor on the development of parkinsonian syndrome in mice

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Intranasal administration of basic fibroblast growth factor prevented or reduced oligokinesia, muscular rigidity, and weight loss and also prevented mortality in mice with parkinsonism induced by repetitive intraperitoneal injections of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine. These beneficial effects are probably due to trophic actions of the factor, whereby the degeneration of nigrostriatal neurons is weakened and delayed and their survival is prolonged.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. G. N. Kryzhanovskii, V. G. Kucheryanu, L. S. Godlevskii, and A. D. mazarati,Byull. Eksp. Biol. Med.,113, No 1, 16–19 (1992).

    Article  CAS  Google Scholar 

  2. B. Cheng and M. P. Mattson,Neuron,7, 1031–1041 (1991).

    Article  PubMed  CAS  Google Scholar 

  3. D. H. Damon,J. Cell Physiol.,138, 221–226 (1989).

    Article  PubMed  CAS  Google Scholar 

  4. I. Date, M. F. D. Notter, S. Y. Felten, and D. L. Felten,Brain Res.,526, 156–160 (1990).

    Article  PubMed  CAS  Google Scholar 

  5. F. Fefti, J. Hartikka, and B. Knusell,Neurobiol. Aging,10, 515–533 (1989).

    Article  Google Scholar 

  6. A. Frese, S. Finkelstein, and M. Di Figlia,Brain Res.,575, 351–355 (1992).

    Article  Google Scholar 

  7. O. Hornykiewicz and S. J. Kish,Adv. Neurol.,45, 19–34 (1986).

    Google Scholar 

  8. B. Knusell,J. Neurosci.,10, No 2, 558–570 (1990).

    Google Scholar 

  9. A. Logan, S. A. Frautschly, A.-M. Gonzalez, and A. Daird,J. Neurosci.,12, No 10, 3828–3837 (1992).

    PubMed  CAS  Google Scholar 

  10. D. J. Otto,J. Neurosci.,10, 1912–1921 (1990).

    PubMed  CAS  Google Scholar 

  11. R. C. Roberts, C. G. Landay, S. P. Finkelstein, and M. Di Figlia,Soc. Neurosci. Abstr.,16, 1231 (1990).

    Google Scholar 

  12. K. Uniickez, S. Engels, and C. Hamm,Ann. Anat.,174, No 5, 405–407 (1992).

    Google Scholar 

  13. D. Zhou and M. Di Figlia,Soc. Neurosci. Abstr.,17, 857 (1991).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of General Nervous System Pathology, Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    G. N. Kryzhanovskii, V. G. Kucheryanu, E. V. Nikushkin & N. A. Krupina

Authors
  1. G. N. Kryzhanovskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. G. Kucheryanu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. V. Nikushkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. A. Krupina
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 9, pp. 260–262, September, 1995

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kryzhanovskii, G.N., Kucheryanu, V.G., Nikushkin, E.V. et al. Influence of basic fibroblast growth factor on the development of parkinsonian syndrome in mice. Bull Exp Biol Med 120, 900–902 (1995). https://doi.org/10.1007/BF02445010

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02445010

Key Words

Search

Navigation