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Effect of the blockade of capsaicin-sensitive nerves on the development of the exudative reaction in immune response and aseptic inflammation

  • Morphology and Pathomorphology
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Abstract

The neurotoxin capsaicin, which depletes some sensory neurons of neuropeptides, is used to explore the role of these neurons in the development of the exudative response induced by zymosan and diphtheria-tetanus-pertussis modified vaccine (DTP-M) in mice. Four hours after the induction of inflammation in capsaicin-treated mice the reaction to DTP is reduced by 52% and delayed-type hypersensitivity to DTP by 26%. No effect of capsaicin is noted on a zymosan-induced exudative reaction.

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Authors and Affiliations

  1. Laboratory of Functional Neuromorphology, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    V. K. Spiridonov & E. M. Zhukova

Authors
  1. V. K. Spiridonov
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  2. E. M. Zhukova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 10, pp. 434–436, October, 1995

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Spiridonov, V.K., Zhukova, E.M. Effect of the blockade of capsaicin-sensitive nerves on the development of the exudative reaction in immune response and aseptic inflammation. Bull Exp Biol Med 120, 1063–1065 (1995). https://doi.org/10.1007/BF02444987

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  • DOI: https://doi.org/10.1007/BF02444987

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