Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 120, Issue 4, pp 1039–1041 | Cite as

The quaternary ammonium salt of conidine oligomer 25 hastens healing of skin wounds in rats

  • V. A. Golenchenko
  • S. A. Silaeva
  • A. V. Gavril'chak
  • A. B. Shekhter
  • A. Ya. Nikolaev
  • V. G. Chumakov
  • V. S. Efimov
Experimental Biology

Abstract

Collagen sponges and films containing a synthetic polycation, the quaternary ammonium salt of conidine oligomer 25, stimulate the repair processes when applied to a wound, accelerating the final epithelialization of skin wounds. The effect of the drug manifests itself mainly during the proliferation and cicatrization stages by speeding up replication and transcription in the fibroblasts and producing intercellular matrix components.

Key Words

skin repair polycation sponges films autoradiography histochemistry 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    K. D. Gladilin and S. E. Rachinskii,Usp. Biol. Khim.,20, 229–256 (1979).Google Scholar
  2. 2.
    P. M. Golovanova, L. R. Makarova, N. N. Tuzova,et al., Byull. Izobret., No 30 (1992).Google Scholar
  3. 3.
    S. A. Silaeva, B. Ya. Khatsernova, V. A. Golenchenko,et al., Vopr. Med. Khim.,36, No 1, 82–84 (1990).PubMedGoogle Scholar
  4. 4.
    L. I. Slutskii,Connective Tissue Biochemistry [in Russian], Leningrad (1969).Google Scholar
  5. 5.
    Yu. P. Taran and L. N. Shishkina,Vopr. Med. Khim.,39, No 1, 37–41 (1993).PubMedGoogle Scholar
  6. 6.
    B. Ya. Khatsernova, S. A. Silaeva, V. A. Golenchenko,et al.,,35, No 3, 83–87 (1989).PubMedGoogle Scholar
  7. 7.
    O. V. Chernova,Antiheparin Activity and Effects of Quaternary Ammonium Salts of Conidine Monodispersed Oligomers on Blood Clotting [in Russian], Author's Synopsis of Thesis of Cand. Med. Sci., Moscow (1983).Google Scholar

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • V. A. Golenchenko
    • 1
    • 2
  • S. A. Silaeva
    • 1
    • 2
  • A. V. Gavril'chak
    • 1
    • 2
  • A. B. Shekhter
    • 1
    • 2
  • A. Ya. Nikolaev
    • 1
    • 2
  • V. G. Chumakov
    • 1
    • 2
  • V. S. Efimov
    • 1
    • 2
  1. 1.I. M. Sechenov Medical AcademyMoscow
  2. 2.Russian State Medical UniversityMoscow

Personalised recommendations