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Correction of testosterone-induced changes in a population of hemopoietic precursors by a bone-marrow inhibitor of the proliferative activity of a hemopoietic stem cell

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A factor inhibiting the proliferation of splenic colony-forming units, injected bothin vivo and after preincubation of mouse bone marrow cellsin vitro, had a dose-dependent effect on the increased proliferative activity of splenic colony-forming units from the bone marrow of mice treated with testosterone propionate. This was associated with a reduction in the number of early hemopoietic precursors of mouse bone marrow. The counts of clonogenic granulocytic-macrophagal and macrophagal colony-forming units decreased and that of burst-forming units in murine bone marrow increased after exposure to the hormone. Testosterone propionate promoted a decrease of the repopulating potential of bone marrow cells, which recovered after their preincubation with the factor inhibiting the proliferation of splenic colony-forming units.

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Authors and Affiliations

  1. Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    I. A. Orlovskaya, S. K. Khaldoyanidi, E. V. Shklovskaya, I. G. Tsyrlova & V. A. Kozlov

Authors
  1. I. A. Orlovskaya
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  2. S. K. Khaldoyanidi
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  3. E. V. Shklovskaya
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  4. I. G. Tsyrlova
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  5. V. A. Kozlov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 10, pp. 394–397, October, 1995

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Orlovskaya, I.A., Khaldoyanidi, S.K., Shklovskaya, E.V. et al. Correction of testosterone-induced changes in a population of hemopoietic precursors by a bone-marrow inhibitor of the proliferative activity of a hemopoietic stem cell. Bull Exp Biol Med 120, 1027–1030 (1995). https://doi.org/10.1007/BF02444975

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  • DOI: https://doi.org/10.1007/BF02444975

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