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Alterations in cardiac function in response to epinephrine in rats with hereditary hypertension (An ECG study)

  • General Pathology and Pathological Physiology
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Abstract

A comparative electrocardiographic evaluation of changes in cardiac function in rats with hereditary arterial hypertension (NISAG strain) and normotensive (Wistar) rats in response to a single epinephrine injection revealed much more pronounced changes in NISAG rats, including an unfavorable time course of electrocardiographic waves (left ventricle overload) and impaired conduction (blockade) and excitability (extrasystoles). The results indicate that the myocardium of NISAG rats is much more responsive to the acute stimulation of adrenergic receptors by epinephrine than is the myocardium of normotensive rats.

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Authors and Affiliations

  1. Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    G. S. Yakobson, A. R. Antonov, V. V. Letyagina, D. G. Sakharov & A. L. Markel'

  2. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    G. S. Yakobson, A. R. Antonov, V. V. Letyagina, D. G. Sakharov & A. L. Markel'

Authors
  1. G. S. Yakobson
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  2. A. R. Antonov
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  3. V. V. Letyagina
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  4. D. G. Sakharov
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  5. A. L. Markel'
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 10, pp. 372–375, October, 1995

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Yakobson, G.S., Antonov, A.R., Letyagina, V.V. et al. Alterations in cardiac function in response to epinephrine in rats with hereditary hypertension (An ECG study). Bull Exp Biol Med 120, 1006–1009 (1995). https://doi.org/10.1007/BF02444968

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  • DOI: https://doi.org/10.1007/BF02444968

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