Abstract
(CBA×C57B1/6) F1 mice injected with zymosan intravenously developed granulomas in the liver; the number of granulomas in mice pretreated with gadolinium chloride, a selective blocker of Kupffer cells, was half that in the untreated animals. Kupffer cells isolated from the liver 5 days after zymosan injection, i.e., during the period when granuloma generation was at its height, displayed a high capacity for stimulating both the luminol-dependent chemiluminescence of blood leukocytes (which is associated with the generation of reactive oxygen species) and the colony-forming activity of bone marrow cells; this capacity was much lower in mice pretreated with gadolinium chloride. It is shown that granulomatous inflammation of the liver is directly dependent on the activity of Kupffer cells.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 10, pp. 366–369, October, 1995
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Tsyrendorzhiev, D.D., Zubakhin, A.A. & Mayanskii, D.N. Granulomatous inflammation of the liver in mice with gadolinium chloride-blocked Kupffer cells. Bull Exp Biol Med 120, 999–1002 (1995). https://doi.org/10.1007/BF02444966
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DOI: https://doi.org/10.1007/BF02444966