Bulletin of Experimental Biology and Medicine

, Volume 120, Issue 1, pp 753–758 | Cite as

Ultrastructural changes in the interstitial cells of the renal medulla during endotoxin shock

  • N. G. Kharlanova
  • Yu. M. Lomov
  • E. A. Bardakhch'yan
Morphology and Pathomorphology


Ultrastructural modifications of renomedullar interstitial cells are described at different stages of experimental endotoxemia in rats and dogs. The dynamics of changes occurring in organelles, lipid granules (precursors of prostaglandins), and medullar capillaries is presented. It is suggested that the alterations in these granules during endotoxin shock are associated with the synthesis, accumulation, and secretion of their precursors in interstitial cells.

Key Words

lipid granules interstitial cells endotoxin shock 


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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • N. G. Kharlanova
    • 1
  • Yu. M. Lomov
    • 1
  • E. A. Bardakhch'yan
    • 1
  1. 1.Laboratory of PathomorphologyAntiplague InstituteRostovon-Don

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