Osteogenesis and angiogenesis during distraction osteosynthesis

Abstract

The volume-spatial organization of osseous tissue and the microarchitectonics of distraction bone regenerating regions of 80 dogs with crus elongation performed after Ilizarov are studied at different stages using the methods of light microscopy, transmission and scanning electron microscopy, and x-ray electron probe microanalysis. It is shown that the rarefaction the interstitial spaces resulting from controlled distension of the bone fragments exerts a stimulatory and orienting effect on angiogenesis. The vascular loops from the proximal and distal fragments and from the paraosseous tissue grow in opposite directions, meet, and intrude into the opposite fragments. Primary osteons develop around these loops. The rapid elongation of osteons insure the growth of the regenerating bone tissue in the desired longitudinal direction.