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Effect of superoxide dismutase on convulsive seizures in rat models of epilepsy

  • Pathological Physiology and General Pathology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Intravenous injections of superoxide dismutase into rats with amygdaline kindling mitigated spontaneous and electrostimulation-induced epileptic seizures and raised the thresholds of electric current for their elicitation; these seizures of reduced intensity were observed during 3 days following chronic (for 6 days) treatment with this enzyme. In contrast, superoxide dismutase injections had no effect on the convulsions induced by electric shock or corazole.

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Authors and Affiliations

  1. Department of Clinical Neurobiology, Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg

    I. V. Gusakov, B. P. Sharonov, T. I. Oparina & D. K. Kambarova

Authors
  1. I. V. Gusakov
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  2. B. P. Sharonov
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  3. T. I. Oparina
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  4. D. K. Kambarova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 7, pp. 20–22, July, 1995

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Gusakov, I.V., Sharonov, B.P., Oparina, T.I. et al. Effect of superoxide dismutase on convulsive seizures in rat models of epilepsy. Bull Exp Biol Med 120, 665–667 (1995). https://doi.org/10.1007/BF02444654

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  • DOI: https://doi.org/10.1007/BF02444654

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