The effect of dialysis membranes on lipid peroxidation in the erythrocytes of patients with terminal renal insufficiency
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The content of malonic dialdehyde is shown to be significantly increased in the erythrocytes of patients as compared to the control. During hemodialysis using a regenerated cellulose membrane, the level of malonic dialdehyde reliably increased after 30 min of treatment (p<0.05) and dropped to the initial level following 180 min of hemodialysis. The level of membrane malonic dialdehyde on the erythrocytes remained at the pre-dialysis level at the 30th and 180th min of hemodialysis when a polysulfone membrane was used. It may be assumed that the activation of lipid peroxidation is due to the interaction of cells with the dialysis membrane and can be considered as one of the markers of biocompatibility.
Key Wordsterminal renal insufficiency erythrocytes dialysis membrane lipid peroxidation
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