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Significance of specific protein S-S bonds in the structural-functional organization of DNA

  • Experimental Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The role of S-S bridges of residual protein in the structural organization of DNA is investigated. The effects of various S-S splitting agents on the naturally occurring DNA-RP protein complexes isolated from various eukaryotic and prokaryotic cells are studied. It is demonstrated that, depending on the incubation conditions, thiols induce dissociation of the DNA-RP complexes to double-strand fragment-DNA subunits of varied size. It is found that the DNA-RP complexes contain specific S-S bonds that may determine different levels of DNA organization in the cromosome.

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Authors and Affiliations

  1. Oncological Research Center, Russian Academy of Medical Sciences, Moscow

    V. A. Struchkov & N. B. Strazhevskaya

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  1. V. A. Struchkov
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  2. N. B. Strazhevskaya
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 180–183, August, 1994

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Struchkov, V.A., Strazhevskaya, N.B. Significance of specific protein S-S bonds in the structural-functional organization of DNA. Bull Exp Biol Med 118, 875–878 (1994). https://doi.org/10.1007/BF02444454

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  • DOI: https://doi.org/10.1007/BF02444454

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