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Genetic basis of adenylatecyclase regulation of testosterone production of Leydig's cells in laboratory mice

  • Experimental Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The function of Leydig's cells during stimulation of various components of the adenylatecyclase system was studied in inbred mice of various lines. Mice of different lines were found to differ markedly in their production of testosterone during stimulation of a crude Leydig's cell suspension with ascending concentrations of chorionic gonadotropin, cholera toxin, forskolin, and dibutyryl-cAMP. The ranking of the lines according to the maximal production of testosterone was virtually the same during exposure to steroidogenesis activators.

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Authors and Affiliations

  1. Department of the Genetic Basis of Neuroendocrine Regulation, Institute of Cytology and Genetics, Siberian

    A. V. Osadchuk & K. V. Svechnikov

  2. Branch of the Russian Academy of Sciences, Novosibirsk

    A. V. Osadchuk & K. V. Svechnikov

Authors
  1. A. V. Osadchuk
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  2. K. V. Svechnikov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 177–179, August, 1994

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Osadchuk, A.V., Svechnikov, K.V. Genetic basis of adenylatecyclase regulation of testosterone production of Leydig's cells in laboratory mice. Bull Exp Biol Med 118, 871–874 (1994). https://doi.org/10.1007/BF02444453

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  • DOI: https://doi.org/10.1007/BF02444453

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