Abstract
A study is performed of the effect of the convulsants picrotoxin and bicuculline, blockers of GABA-dependent Cl−-conductivity, on the rate of desensitization of muscimol-induced36Cl− entry into synaptoneurosomes isolated from rat cortex. Both picrotoxin and bicuculline, despite the difference in the mechanisms of inhibition of the GABA receptor/Cl− ionophore complex, markedly reduce the rate of desensitization. However, the initial moment of the action of both convulsants is characterized by inhibition of Cl− transport alone, without a drop of the rate of desensitization.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
G. N. Kryzhanovskii, I. G. Rebrov, and R. N. Glebov,Byull. Esp. Biol. Med.,114, No 9, 249–251 (1992).
P. R. Adams and D. A. Brown,J. Physiol. (Lond.),250, 85–120 (1975).
D. J. Cash and K. Subbarao,Biochemistry,26, 7556–7562 (1987).
M. P. Frosch, S. A. Lipton, and M. A. Ditcher,J. Neurosci.,12, No 8, 3042–3053 (1992).
R. W. Olsen and F. Leeb-Lundberg, in:GABA and Benzodiazepine Receptors. Eds. E. Costa, G. DiChiara, and G. L. Gessa, New York (1981), pp. 93–102.
R. Ramanjaneyulu and M. J. Ticku,Europ. J. Pharmacol.,98, 337–345 (1986).
A. J. Turner and S. R. Whittle,Biochem. J. 209, 29–41 (1983).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 160–163, August, 1994
Rights and permissions
About this article
Cite this article
Rebrov, I.G., Kryzhanovskii, G.N., Belykh, N.P. et al. Effect of picrotoxin and bicuculline on desensitization of the GABA receptor/Cl− ionophore complex. Bull Exp Biol Med 118, 852–855 (1994). https://doi.org/10.1007/BF02444447
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02444447