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Increased anxiety and reduced pain sensitivity in offspring of rats after prenatal morphinization

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Administration of morphine to outbred female rats is shown to result in increased anxiety in the conflict test and reduced pain sensitivity in the tail flick test in 2.5-monthold offspring. In prenatally morphinized offspring the analgetic effect of morphine was enhanced, while the anxiolytic effect of buspirone was lower than in intact animals, which suggests rearrangements in the opioid and serotoninergic systems of the brain.

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Authors and Affiliations

  1. Laboratory of Psychopharmacology, Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    T. A. Voronina, N. G. Chobanov, G. M. Molodavkin & V. N. Zhukov

Authors
  1. T. A. Voronina
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  2. N. G. Chobanov
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  3. G. M. Molodavkin
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  4. V. N. Zhukov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 154–156, August, 1994

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Voronina, T.A., Chobanov, N.G., Molodavkin, G.M. et al. Increased anxiety and reduced pain sensitivity in offspring of rats after prenatal morphinization. Bull Exp Biol Med 118, 844–846 (1994). https://doi.org/10.1007/BF02444445

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  • DOI: https://doi.org/10.1007/BF02444445

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