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Effect of catalin on radical production in aqueous solutions and cross-linking in deoxyribonucleoprotein complex

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of catalin on cross-linking in the DNA-protein system is studied after illumination with visible and UV light. Catalin is shown to stimulate this process. The use of a hydroxylamine trap reveals that catalin (10–100 μM) induces the accumulation of free radicals in aqueous solutions as soon as 10 minutes after irradiation. A considerable amount of O -2 is fixed in the medium during illumination of catalin aqueous solution. Superoxide dismutase added to the incubation medium considerably reduced the number of recorded radicals.

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Authors and Affiliations

  1. Laboratory of Physicochemical Regulation of Cell Metabolism, Laboratory of Physicochemical Methods of Study of Nucleic Acids, N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow

    N. B. Polyanskii, V. I. Binyukov & E. Mil'

  2. Group of Membrane Biochemistry A. N. Bakh Institute of Biochemistry, Russian Academy of Sciences, Moscow

    N. B. Polyanskii, V. I. Binyukov & E. Mil'

Authors
  1. N. B. Polyanskii
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  2. V. I. Binyukov
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  3. E. Mil'
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 142–144, August, 1994

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Polyanskii, N.B., Binyukov, V.I. & Mil', E. Effect of catalin on radical production in aqueous solutions and cross-linking in deoxyribonucleoprotein complex. Bull Exp Biol Med 118, 831–834 (1994). https://doi.org/10.1007/BF02444441

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  • DOI: https://doi.org/10.1007/BF02444441

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