Skip to main content
SpringerLink
Log in

Use of zinc metallothioneine to protect mice from ionizing radiation

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Injecting mice with exogenous zinc-metallothioneine from rat liver at 2 mg/kg 5–10 min before their total-body irradiation resulted in a significantly increased 30-day survival rate. The radioprotective effect of zinc-metallothioneine was not associated with the influence of its constituents, since a model mixture composed of these (albumin, cysteine, and zinc) failed to protect.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. N. I. Gracheva, M. Z. Kapitskaya, R. N. Krutilina,et al., Radiobiologiya,29, No 6, 737–741 (1989).

    CAS  Google Scholar 

  2. A. N. Koterov, A. Yu. Sazykin, and I. V. Filippovich,,33, No 1, 122–127 (1993).

    CAS  Google Scholar 

  3. A. N. Koterov, A. Yu. Sazykin, and I. V. Filippovich,Byull. Eksp. Biol. Med.,115, No 1, 39–40 (1993).

    Article  CAS  Google Scholar 

  4. J. Abel, and N. de Ruiter,Toxicol. Lett.,47, No 2, 191–196 (1989).

    Article  PubMed  CAS  Google Scholar 

  5. A. Bakka, A. S. Johnsen, L. Endresen, and H. E. Rugstad,Experientia,38, No 3, 381–383 (1982).

    Article  PubMed  CAS  Google Scholar 

  6. J. W. Bauman, J. Liu, Y. P. Liu, and C. D. Klaassen,Toxicol. Appl. Pharmacol.,110, No 2, 347–354 (1991).

    Article  PubMed  CAS  Google Scholar 

  7. L. S. Chubatsu and R. Meneghini,Biochem. J.,291, Part 1, 193–198 (1993).

    PubMed  CAS  Google Scholar 

  8. C. L. Greenstock, C. P. Jinot, R. P. Whitehouse, and et al.,Free Radic. Res. Commun.,2, No 4, 233–239 (1987).

    PubMed  CAS  Google Scholar 

  9. H. Lohrer and T. Robson,Carcinogenesis,10, No 12, 2279–2284 (1989).

    PubMed  CAS  Google Scholar 

  10. M. A. Lynes, J. S. Garvey, and D. A. Lawrence,Molec. Immunol.,27, No 3, 211–219 (1990).

    Article  CAS  Google Scholar 

  11. J. Matsubara,Experientia (Suppl.),52, 603–612 (1987).

    CAS  Google Scholar 

  12. M. J. Renan and P. I. Dowman,Radiat. Res.,120, No 3, 442–455 (1989).

    PubMed  CAS  Google Scholar 

  13. M. Satoh, N. Miura, A. Naganuma,et al., Europ. J. Cancer Clin. Oncol.,25, No 12, 1727–1731 (1989).

    Article  PubMed  CAS  Google Scholar 

  14. D. M. Templeton and M. G. Cherian,Methods Enzymol.,205, 11–24 (1991).

    Article  PubMed  CAS  Google Scholar 

  15. P. J. Thornalley and M. Vasak,Biochim. Biophys. Acta,827, No 1, 36–44 (1985).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biophysics, Ministry of Health of the Russian Federation, Moscow

    A. N. Koterov, Z. A. Trebenok & I. V. Filippovich

Authors
  1. A. N. Koterov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Z. A. Trebenok
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. V. Filippovich
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 139–141, August, 1994

Rights and permissions

Reprints and permissions

About this article

Cite this article

Koterov, A.N., Trebenok, Z.A. & Filippovich, I.V. Use of zinc metallothioneine to protect mice from ionizing radiation. Bull Exp Biol Med 118, 828–830 (1994). https://doi.org/10.1007/BF02444440

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02444440

Key Words

Search

Navigation