Abstract
The rat model of a neuropathic pain syndrome (transection of the sciatic nerve with encapsulation of its central end) was used to evaluate the efficacy of the antioxidant α-tocopherol in such syndromes. It was found that administration of α-tocopherol 3 days before nerve transection and then for 3 weeks thereafter it delayed the development of the pain syndrome, which subsequently tended to subside. In contrast, a 3-week α-tocopherol treatment started when the pain syndrome had already set in failed to influence its evolution. α-Tocopherol markedly reduced manifestations of inflammatory and degenerative processes in the denervated limb.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 8, pp. 123–125, August, 1994
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Danilova, E.I., Grafova, V.G. & Reshetnyak, V.K. Effects of α-tocopherol in rats with a neuropathic pain syndrome. Bull Exp Biol Med 118, 809–812 (1994). https://doi.org/10.1007/BF02444434
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DOI: https://doi.org/10.1007/BF02444434