Bulletin of Experimental Biology and Medicine

, Volume 118, Issue 1, pp 796–798 | Cite as

Dehydrogenase systems of different rat tissues in experimental alcoholism simulated by inhalation or forced intake of ethanol

  • M. S. Usatenko
  • P. D. Shabanov
  • M. A. Petrova
  • I. K. Yaichnikov
Methodology
  • 18 Downloads

Abstract

It is shown that alcoholization of rats during 1.5 months by the inhalation of ethanol vapors with a long-term subsidence into narcotic sleep results in alcohol dependence and marked shifts in the ratio between the activity of malate and lactate dehydrogenases and a change in the isoenzyme spectrum of the latter. This leads to an enhancement of aerobic processes in the brain and skeletal muscle tissues and of anaerobic processes in the liver and myocardium. Semiforced alcoholization of rats during 11 months, with ethanol solution serving as the only soruce of liquid, moderately lowers the ethanol tolerance and does not affect the dehydrogenase activity in the tissues examined. The effects of ethanol on the activity of functionally associated enzyme systems of malate and lactate dehydrogenases are believed to depend on the method of alcoholization and the type of tissue.

Key Words

dehydrogenases ethanol simulation of alcoholism carbohydrate metabolism 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • M. S. Usatenko
    • 1
  • P. D. Shabanov
    • 1
  • M. A. Petrova
    • 1
  • I. K. Yaichnikov
    • 1
  1. 1.Medical Academy of Postgraduate StudiesSt. Petersburg

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