Skip to main content
SpringerLink
Log in

Changes in the blood-brain barrier in experimental cirrhosis of the liver

  • Morphology and Pathomorphology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Light and electron microscopic studies on Wistar rats with experimental cirrhosis produced by tetrachloromethane demonstrate strongly marked changes in the blood-brain barrier, particularly in capillaries and vascular pedicles of astrocytes. It is pointed out that destabilization of the blood-brain barrier favors the transfer of cerebral toxins and other metabolic poisons across this barrier.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. Bradbury,The Concept of a Blood-Brain Barrier, Wiley-Interscience (1979).

  2. G. Velev and G. Shumkov,Eksp. Med. Morfol. (Bulgaria),4, No. 3, 135–139 (1975).

    Google Scholar 

  3. D. N. Mayanskii,Kupffer's Cells and the System of Mononuclear Phagocytes [in Russian], Novosibirsk (1981).

  4. A. A. Pal'tsyn and B. V. Vtyurin,Trudy Nauchn.-Issled Inst. im. Sklifosovskogo [in Russian], Vol. 18, Moscow (1978), pp. 71–73.

    Google Scholar 

  5. V. P. Fedorov, I. B. Ushakov, A. N. Kordenko,et al., Izv. Akad. Nauk SSSR, Ser. Biol., No. 1, 24–34 (1989).

    PubMed  Google Scholar 

  6. A. Fischer,Physiology and Experimental Pathology of the Liver [Russian translation], Budapest (1961).

  7. A. W. Ham and D. H. Cormack,Histology, 8th ed., Lippincott (1979).

  8. A. M. Chernukh, N. N. Aleksandrov, and O. V. Alekseev,Microcirculation [in Russian], Moscow (1975).

  9. V. A. Shakhlamov,Capillaries [in Russian], Moscow (1971).

  10. K. Altermann,Arch. Pathol.,57, No. 1, 1–11 (1954).

    Google Scholar 

  11. H. Moon,Amer. J. Pathol.,26, 1041–1052 (1950).

    CAS  Google Scholar 

  12. J. Muller,Arch. Exp. Path. Pharmacol.,109, 276–294 (1925).

    Article  CAS  Google Scholar 

  13. I. Rhodin,Ultrastruct. Res.,25, 450–455 (1968).

    Article  Google Scholar 

  14. V. Schwarzmann,Rev. Int. Hepatol.,7, No. 5, 387–429 (1957).

    PubMed  CAS  Google Scholar 

  15. H. Zimmerman,Hepatotoxicity: the Adverse Effects of Drugs and Other Chemicals on the Liver, New York (1978).

Download references

Author information

Authors and Affiliations

  1. Department of Nervous Diseases with a Course in Neurosurgery, Medical Institute of Sanitation and Hygiene, St. Petersburg

    V. A. Mishchenko, O. A. Goryukhina & R. D. Ilyuk

Authors
  1. V. A. Mishchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. A. Goryukhina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. D. Ilyuk
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 7, pp. 86–88, July, 1994

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mishchenko, V.A., Goryukhina, O.A. & Ilyuk, R.D. Changes in the blood-brain barrier in experimental cirrhosis of the liver. Bull Exp Biol Med 118, 771–774 (1994). https://doi.org/10.1007/BF02444382

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02444382

Key Words

Search

Navigation