Abstract
Chronic intoxication of rats with morphine during 2- and 4-week periods resulted in the emergence of antimorphine antibodies in the blood of 50 and 80% of the animals, respectively, in hemagglutination titers 1∶20 and higher. Antibodies were not detected in the control animals (not treated with morphine) but were detected in 17% of rats given alcohol during a 3-month period. The animals with a high titer of antimorphine antibodies displayed a lower level of humoral reactivity in response to immunization with a thymus-dependent antigen (sheep erythrocytes) compared with the animals with a low titer of the antibodies.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 7, pp. 74–76, July, 1994
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Gamaleya, N.B., Mondrus, K.A., Tronnikov, S.I. et al. Antimorphine antibodies as an indicator of chronic morphine intoxication and impaired immunological reactivity. Bull Exp Biol Med 118, 758–760 (1994). https://doi.org/10.1007/BF02444378
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DOI: https://doi.org/10.1007/BF02444378