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Involvement of fibronectin and interacting serum components in the regulation of activity of human natural killer cells

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The cytotoxic activity of natural killer cells and the intensity of conjugate formation are studiedin vitro in the natural cytotoxicity reaction against3H-uridine-labeled human erythromyeloleukotic cells K-562 in the presence of fibronectin, γ-globulin, and fibronectin/γ-globulin combination. It is demonstrated that fibronectin does not change natural cytotoxicity, γ-globulin increases the activity of human natural killer cells, and the fibronectin — γ-globulin combination increases both the intensity of conjugate formation and the cytotoxic activity of natural killer cells.

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References

  1. A. ya. Kul'berg, in:Regulatory R-Proteins in Infectious and other Diseases [in Russian], Moscow (1990), pp. 3–9.

  2. A. Ya. Kul'berg, and A. O. Anderson, in:Problems of Infectology [in Russian], Moscow (1991), pp. 240–250.

  3. A. Ya. Kul'berg, I. A. Elistratova, I. A. Tarkhanova,et al., Immunologiya, No 2, 14–18 (1986).

    Google Scholar 

  4. M. Billaud, A. Calender, J.-M. Seigneurin, and G. M. Lenoir,Lancet, Dec. 5, 1327–1328 (1987).

    Article  Google Scholar 

  5. C. J. Froelich and A. D. Bankhurst,Clin. Exp. Immunol.,55, No 3, 664–670 (1984).

    PubMed  CAS  Google Scholar 

  6. P. Garcia-Penarrubia, F. T. Kostler, and A. D. Bankhurst,Natur. Immun. Cell Growth Regulat.,8, No 2, 57–65 (1989).

    CAS  Google Scholar 

  7. A. Gismondi, S. Morrone, M. J. Humphries,et al., J. Immunol.,146, No 1, 384–392 (1991).

    PubMed  CAS  Google Scholar 

  8. T. Haliotis, J. Roder, M. Klein,et al., J. Exp. Med.,151, 1039–1048 (1980).

    Article  PubMed  CAS  Google Scholar 

  9. Y. Hashimoto and H. Sudo,Gann.,62, No 2, 139–143 (1971).

    PubMed  CAS  Google Scholar 

  10. M. Jondal, C. Kullman, M. Alter, and K. Ljunggren,Cell. Immunol.,100, No 1, 158–166 (1986).

    Article  PubMed  CAS  Google Scholar 

  11. J. Mysliwska, J. Bigda, and A. Mysliwski,Acta Histochem.,22, No 1, 127–131 (1987).

    Google Scholar 

  12. M. Robertson, M. A. Caligiuri, T. J. Manley,et al., J. Immunol.,145, No 10, 3194–3201 (1990).

    PubMed  CAS  Google Scholar 

  13. F. F. Roossien, P. E. de Kuiper, D. Rijk, and E. Ross,Cancer Res.,50, No 12, 3509–3513 (1990).

    Google Scholar 

  14. M. Salvarrey and A. Rostagno,Clin. Exp. Immunol.,76, No 1, 92–98 (1989).

    PubMed  CAS  Google Scholar 

  15. A. Santoni, A. Gismondi, S. Morrone,et al., J. Immunol.,143, No 7, 2415–2421 (1989).

    PubMed  CAS  Google Scholar 

  16. A. Santoni, A. Gismondi, R. Paolini,et al., Cytotechnology,5, Suppl. 1, 117–121 (1991).

    Article  Google Scholar 

  17. T. P. Sheeran, F. R. Jackson, P. T. Dawes,et al., J. Immunol. Meth.,115, No 1, 95–98 (1988).

    Article  CAS  Google Scholar 

  18. I. Virtanen, J. Ylanne, T. Vartio, and E. Sacsela,Scand. J. Immunol.,33, No 4, 421–428 (1991).

    Article  PubMed  CAS  Google Scholar 

  19. G. Wolter, L. Kuijpers, J. Kacaki, and A. H. W. M. Schuurs,J. Clin. Pathol.,26, 873–879 (1976).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Immunochemistry, N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow

    S. B. Cheknev, D. V. Kuyavskaya, I. A. Tarkhanova, E. E. Babaeva, L. M. Bartova & A. Ya. Kul'berg

Authors
  1. S. B. Cheknev
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  2. D. V. Kuyavskaya
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  3. I. A. Tarkhanova
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  4. E. E. Babaeva
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  5. L. M. Bartova
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  6. A. Ya. Kul'berg
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 7, pp. 54–59, July, 1994

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Cheknev, S.B., Kuyavskaya, D.V., Tarkhanova, I.A. et al. Involvement of fibronectin and interacting serum components in the regulation of activity of human natural killer cells. Bull Exp Biol Med 118, 737–742 (1994). https://doi.org/10.1007/BF02444373

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  • DOI: https://doi.org/10.1007/BF02444373

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