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Effect of ionenes on ion permeability of erythrocyte membranes

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Ionophore activity of ionenes, like that of polymyxins, is shown to be potentiated by long-chain antiions. Rapid stoichiometric anion equilibration in isoosmotic buffered sugar medium revealed that the amplitude of Cl−/OH− exchange in erythrocytes induced by an ionene-detergent complex gradually drops with the decrease of both the charge density and the number of monomeric moieties in the polymeric chain. This is also paralleled by passive K+ leakage from the cells.

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Authors and Affiliations

  1. Department of Pharmacology of Homeostasis, Department of Biophysics, Medico-Biological Faculty, Russian State Medical University, Moscow

    O. A. Golovleva, E. A. Korepanov, V. S. Efimov & Yu. A. Vladimirov

Authors
  1. O. A. Golovleva
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  2. E. A. Korepanov
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  3. V. S. Efimov
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  4. Yu. A. Vladimirov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 7, pp. 44–46, July, 1994

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Golovleva, O.A., Korepanov, E.A., Efimov, V.S. et al. Effect of ionenes on ion permeability of erythrocyte membranes. Bull Exp Biol Med 118, 725–727 (1994). https://doi.org/10.1007/BF02444369

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  • DOI: https://doi.org/10.1007/BF02444369

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