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Protective effect of the lysosomotropic preparation rheopolyglucin in the treatment of iron deficiency anemia with iron saccharate

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Levels, phagocytic capacity, and ultrastructure of Kupffer's cells and plastic processes in these cells were studied in Chinchilla rabbits with severe posthemorrhagic iron deficiency anemia (IDA) after their treatment with the iron-containing preparation Ferrum Lek (FL) alone or in combination with the dextran preparation Rheopolyglucin (RPG). In the rabbits treated with FL only, both the phagocytic capacity and number of Kupffer's cells were substantially reduced, whereas in those given FL after being injected with RPG the phagocytic capacity of Kupffer's cells approached that in the intact controls and their numbers exceeded the control level. The level of plastic processes in Kupffer's cells was significantly lowered in the untreated rabbits with IDA and even more so in those treated with FL alone. Preinjecting FL-treated rabbits with RPG led to an intensification of synthetic processes in Kupffer's cells and lowered FL levels in their secondary lysosomes.

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Authors and Affiliations

  1. Department of Pathological Anatomy, Medical Institute, Novosibirsk

    T. A. Ageeva & V. A. Shkurupii

Authors
  1. T. A. Ageeva
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  2. V. A. Shkurupii
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 7, pp. 40–43, July, 1994

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Ageeva, T.A., Shkurupii, V.A. Protective effect of the lysosomotropic preparation rheopolyglucin in the treatment of iron deficiency anemia with iron saccharate. Bull Exp Biol Med 118, 721–724 (1994). https://doi.org/10.1007/BF02444368

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  • DOI: https://doi.org/10.1007/BF02444368

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