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Bulletin of Experimental Biology and Medicine

, Volume 118, Issue 1, pp 718–720 | Cite as

Radioprotective action of lymphokinin, a composite preparation of cytokines

  • V. N. Boiko
  • O. V. Shadrin
  • I. G. Derevyanchenko
  • A. M. Buntsevich
  • S. N. Bykovskaya
Pharmacology and Toxicology
  • 16 Downloads

Abstract

Lymphokinin injected into mice in a dose of 25,000 U/kg intraperitoneally before or after their single irradiation producing acute radiation sickness is found to prolong their survival. The optimal time for administering Lymphokinin depends on the radiation dose. Its survival-prolonging effect is most marked when it is injected 1 h or 24 h before or 23 h after exposure to a dose of 6.0 Gy.

Key Words

Lymphokinin (a composite preparation of cytokines) radiation radiation protection survival 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • V. N. Boiko
    • 1
    • 2
  • O. V. Shadrin
    • 1
    • 2
  • I. G. Derevyanchenko
    • 1
    • 2
  • A. M. Buntsevich
    • 1
    • 2
  • S. N. Bykovskaya
    • 1
    • 2
  1. 1.Center for Cancer ResearchRussian Academy of Medical SciencesMoscow
  2. 2.Research Institute of Military MedicineMinistry of DefenceSt. Petersburg

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