Rat brain gangliosides during hypoxia
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The content and composition of rat brain gangliosides in various forms of hypoxia is studied. The content of lipid-bound sialic acid is found to be considerably elevated in the earliest stages of hypoxia combined with hypercapnia and cooling. The content of gangliosides remains elevated over the hypoxia period and returns to control values 48 hours after its discontinuation. Repeated hypoxia results in the same changes in rat brain gangliosides. Hemic sodium nitrite-induced hypoxia also leads to a reliable elevation of these lipids. Hypoxia also causes changes in the content of individual ganglioside fractions: a decreased content of mono- and an increased content of polysialogangliosides.
Key Wordsgangliosides sodium nitrite hypoxia brain rats
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