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Protective hepatotropic effect of preparations from mytilidae and ginseng in animals given dioctyl phthalate

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is shown that in a group of animals given dioctyl phthalate alone antipyrine metabolism is enhanced (the urine content of its metabolites rises), and the histological structure of the liver is altered by the end of the experiment: the plasmalemma membranes, the granular endoplasmic reticulum, and mitochondria are destroyed, and fat deposits are observed in the disrupted zones of the mitochondria. In animals given dioctyl phthalate and adaptogens simultaneously antipyrine metabolism normalizes, and the morphological structure of the liver changes slightly, although it does not normalize.

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Authors and Affiliations

  1. Research Clinical Institute of the Moscow Region, Moscow

    R. V. Gorenkov, P. N. Lyubchenko, V. B. Potapova, E. A. Bendikov, A. V. Petrakov, V. V. Ul'yanova, T. V. Besedina & L. I. Slepyan

  2. Central Research Institute of Gastroenterology, Moscow

    R. V. Gorenkov, P. N. Lyubchenko, V. B. Potapova, E. A. Bendikov, A. V. Petrakov, V. V. Ul'yanova, T. V. Besedina & L. I. Slepyan

  3. All-Russia Research Institute of Fisheries and Oceanography, St. Petersburg

    R. V. Gorenkov, P. N. Lyubchenko, V. B. Potapova, E. A. Bendikov, A. V. Petrakov, V. V. Ul'yanova, T. V. Besedina & L. I. Slepyan

  4. Chemico-Pharmaceutical Institute, St. Petersburg

    R. V. Gorenkov, P. N. Lyubchenko, V. B. Potapova, E. A. Bendikov, A. V. Petrakov, V. V. Ul'yanova, T. V. Besedina & L. I. Slepyan

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  1. R. V. Gorenkov
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  2. P. N. Lyubchenko
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  3. V. B. Potapova
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  4. E. A. Bendikov
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  5. A. V. Petrakov
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  6. V. V. Ul'yanova
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  7. T. V. Besedina
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  8. L. I. Slepyan
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 5, pp. 550–554, May, 1994

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Gorenkov, R.V., Lyubchenko, P.N., Potapova, V.B. et al. Protective hepatotropic effect of preparations from mytilidae and ginseng in animals given dioctyl phthalate. Bull Exp Biol Med 117, 552–557 (1994). https://doi.org/10.1007/BF02444316

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  • DOI: https://doi.org/10.1007/BF02444316

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